Physician at the department of Ophthalmology, Lund University Hospital, Sweden
Research interest: Inherited retinal diseases, gene replacement therapy.

 

PhD at Lund University May 14th 2010

 

Supervisors:                              Faculty opponent:
Prof. Sten Andréasson          Eeva-Marja Sankila, MD, PhD

Doc. Vesna Ponjavic              Helsinki University Hospital, Universitetssjukhuset i Lund Finland

 

Thesis:

X-linked retinoschisis

electrophysiology, molecular genetics and treatment

• 2008 Nov	-		Current position Physician (resident) at the Department of Ophthalmology, Lund University Hospital, Sweden
  2003 Oct	-	2008 Oct	Visiting fellow at the National Institute of Health, National Institute on Deafness and Other Communication Disorders, Section for Translation Research in Retinal and Macular Degeneration.
  			Attended Electrophysiology in Animal Models of Eye Disease (Conference & Training Workshop) 2-3 June 07 John Hopkins University, Wilmer Eye Institute, Baltimore, MD, USA   Software development for recording and analyzing full-field ERG – 2007
  2001 Sep	-	2003 Oct	Physician (resident) at the Department of Ophthalmology, Lund University Hospital, Sweden
  2001 May	-	2001 Aug	Physician, Department of Ophthalmology, County Hospital Kalmar, Sweden
  2001 May			License to practice medicine
  1999 Nov	-	2001 Apr	Internship 18 month (Allmäntjänstgöring) , County Hospital Kalmar, Sweden
  1999 Jul	-	1999 Oct	General Practician, Kävlinge primary care center, Sweden
  1994 Jan	-	1999 Jun	Medical Doctor, Lund University, Sweden
  1990 Jul	-	1994 Jan	Biomedical engineer with focus on electrophysiology and imaging, County Hospital Kalmar, Sweden
  1990 Jan	-	1990 Jun	Engineer in electronics, Apptronic, Kalmar, Sweden
  1988 Oct		1989 Dec	Engineer in electronics, Swedish navy
  1988 Jun			Graduate of Lars Kaggskolan, Kalmar, Sweden, Four year high school technology program, electronic engineering branch

  
  

Original papers

3. Kjellström S., Vijayasarathy C., Ponjavic V., Sieving P.A. and Andréasson S. Long-term 12 year follow-up of X-linked congenital retinoschisis. Ophthalmic Genetics 2010, In Press

Park TK, Wu, Kjellstrom S, Zeng Y, Bush R.A, Sieving P.A, Colosi P. (2009). "Intravitreal delivery of AAV8 retinoschisin results in cell type-specific gene expression and retinal rescue in the Rs1-KO mouse." Gene therapy 2009;16(7): 916-26

Haruta M, Bush RA, Kjellstrom S, Le Y, Camasamudram V., Sieving P.A. Depleting Rac1 component of NADPH oxidase in mouse photoreceptors protects from photo-oxidative stress without affecting rod structure. Proc Natl Acad Sci U S A 2009;106(23): 9397-402.

 

Luna, G., S. Kjellstrom, et al. "Transient Retinal Detachment Reduces Cavity Size and does not Exacerbate the Glial and Neural Remodeling in a Mouse Model of X-Linked Retinoschisis."  Invest Ophthalmol Vis Sci 2009;50:3977-3984.

 

Ahmed ZM, Kjellström S, Haywood-Watson RJ, Bush RA, Hampton LL, Battey JF, Riazuddin S, Frolenkov G, Sieving PA, Friedman TB. Double homozygous waltzer and Ames waltzer mice provide no evidence of retinal degeneration.Mol Vis. 2008;14:2227-36.

 

Cardiakidis Myers A, Kjellström S, Bruun A, Isaksson B, Andréasson S, Ponjavic V Rifabutin accumulates in lens and reduces retinal function in rabbit eye. Retina. 29(1):106-111, January 2009

 

Takada, Y., Vijayasarathy, C., Zeng, Y., Kjellstrom, S., Bush, R.A., Sieving, P.A Synaptic pathology in retinoschisis knockout (Rs -/y) mouse retina and modification by rAAV-Rs1 gene delivery. Investigative ophthalmology & visual science. 2008 Aug;49(8):3677

 

Brooks BP, Larson DM, Chan CC, Kjellstrom S, Smith RS, Crawford MA, Lamoreux L, Huizing M, Hess R, Jiao X, Hejtmancik JF, Maminishkis A, John SW, Bush R, Pavan WJ. Analysis of ocular hypopigmentation in Rab38cht/cht mice. Invest Ophthalmol Vis Sci. 2007 Sep;48(9):3905-13.

 

Kjellstrom S, Bush R A., Zeng Y, Takada Y, Sieving P A. Retinoschisin Gene Therapy and Natural History in the Rs1h-KO Mouse: Long-term Rescue from Retinal Degeneration. Invest Ophthalmol Vis Sci2007;48(8):3837-3845

 

Wen R, Song Y, Kjellstrom S, Tanikawa A, Liu Y, Li Y, Zhao L, Bush RA, Laties AM, Sieving PA. Regulation of rod phototransduction machinery by ciliary neurotrophic factor. J Neurosci. 2006 Dec 27;26(52):13523-30.

 

Kjellstrom S, Bruun A, Isaksson B, Eriksson T, Andreasson S, Ponjavic V. Retinal function and histopathology in rabbits treated with Topiramate.
Doc Ophthalmol. 2006 Nov;113(3):179-86. Epub 2006 Nov 18.

 

Haywood-Watson RJ , Ahmed ZM, Kjellstrom S(shared 1st author), Bush RA, Takada Y, Hampton LL, Battey JF, Sieving PA, Friedman TB. Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3074-84.

 

Kjellstrom U, Kjellstrom S, Bruun A, Andreasson S, Ponjavic V. Retinal function in rabbits does not improve 4-5 months after terminating treatment with vigabatrin. Doc Ophthalmol. 2006 Jan;112(1):35-41.

 

Ponjavic V, Granse L, Kjellstrom S, Andreasson S, Bruun A. Alterations in electroretinograms and retinal morphology in rabbits treated with vigabatrin. Doc Ophthalmol. 2004 Mar;108(2):125-33.

 

Zeng Y, Takada Y, Kjellstrom S, Hiriyanna K, Tanikawa A, Wawrousek E, Smaoui N, Caruso R, Bush RA, Sieving PA. RS-1 Gene Delivery to an Adult Rs1h Knockout Mouse Model Restores ERG b-Wave with Reversal of the Electronegative Waveform of X-Linked Retinoschisis. Invest Ophthalmol Vis Sci. 2004 Sep;45(9):3279-85

Abstracts / posters

 

Evaluation of retinal function and morphology in rabbits treated with vigabtrin in comparison to normal rabbits. Kjellström S, Gränse L, Andréasson S, Bruun A, Ponjavic V Invest Ophthalmol Vis Sci (ARVO suppl) 2003

Adenovirus - Associated Virus ( AAV ) Mediated Delivery of Lens Epithelium Derived Growth Factor ( LEDGF ) Preserves Photoreceptor Function in RCS Rats . R.A. Bush, Y.Zen, D.Raz-Pra1, S.Kjellstrom, M.Santos-Muffley, P.A. Sieving (Poster ARVO 2005)

Iris and Retinal Pigment Epithelium Atrophy in Rab38cht/cht Mice
B.P. Brooks, D.M. Larson, C.-C.Chan, S.Kjellstrom, R.S. Smith, M.Huizig, F.J. Hejtmancik, S.W. M. John, P.A. Sieving, W.J. Pavan. .(Poster ARVO 2005)

Retinal Function and Morphology of Retina and Brain in Rabbits Treated With Per Oral Topiramate. S.Kjellstrom, A.Bruun, M.-L.Smith, B.Isaksson, T.Eriksson, S.Andréasson, V.Ponjavic .(Poster ARVO 2005)

Evaluation of Retinal Function and Morphology in Rabbits Several Months After Terminating Treatment With Vigabatrin. U.Kjellstrom, S.Kjellstrom, A.Bruun, S.Andréasson, V.Ponjavic.(Poster ARVO 2005)

Nrl Is Sufficient for the Differentiation of Functional Rods E.C. T. Oh, S.Kjellstrom, R.A. Bush, J.Bennett, P.A. Sieving, A.Swaroop.(Poster ARVO 2005)

Adeno-Associated Virus (AAV)-Mediated Delivery Of Lens Epithelium Derived Growth Factor (LEDGF) Preserves Photoreceptor Function In Retinal Degeneration In The Absence Of Small Heat Shock Protein Up-Regulation R.A. Bush, Y. Zeng, D. Raz-Prag, S. Kjellstrom, M. Santos-Muffley, and P.A. Sieving (Poster NIH Research Festival 2005)

Deafness in Ames Waltzer mice is accompanied by reduced electroretinogram amplitudes. Kjellstrom et al .(Poster ARVO 2006)

Reduced full-field Electroretinogram (ERG) and lens deposit in rabbits treated with Rifabutin. Ponjavic, Kjellstrom et al. (Poster ARVO 2006)

Retinal Changes Following Experimental Retinal Detachment in the Retinoschisin Knockout Mouse. S.K. Fisher, M.R. Verardo, J.Byun, G.P. Lewis, G.Luna, S.Kjellstrom, P.Sieving . Invest Ophthalmol Vis Sci (ARVO suppl) 2007

Long Term Retinal Rescue in Retinoschisis Mouse Model by AAV-Gene Transfer S.Kjellstrom, Y.Zeng, Y.Takada, R.Bush, P.Sieving. Nei/nidcd/strrmd, National Eye Inst/NIH, Bethesda, MD. Invest Ophthalmol Vis Sci (ARVO suppl) 2007

CNTF Negatively Regulates the Phototransduction Machinery in Rod Photoreceptors: Implications for Light-Induced Photostasis Plasticity. Wen, Y.Song, S.Kjellstrom, A.Tanikawa, Y.Liu, Y.Li, L.Zhao, R.A. Bush, A.M. Laties, P.A. Sieving. Invest Ophthalmol Vis Sci (ARVO suppl) 2007

Retinoschisin gene transfer therapy alters natural history of retinal degeneration Rs1h-KO mouse and gives long term rescue Sten Kjellstrom, Ronald A Bush, Yuichiro Takade, Yong Zheng, Paul A Sieving ISCEV XLV symposium 2007, Hyderabad, India Doc Ophthalmologica Vol115, Number 1 / July, 2007

Intravitreal Administration of an AAV8 Retinoschisin Vector to the RS1-KO Mouse Results in Cell Type-Specific Gene Expression and Rescue of the Disease Phenotype T. Park, Z. Wu, S. Kjellstrom, Y. Zeng, R. A. Bush, P. A. Sieving, and P. Colosi (Poster ARVO 2006)

 

Lectures by invitation

 

November 17-18 2006 Lund University, Sweden ”Kliniska elektrofysiologiska metoder för utredning av synfunktionen vid retinala sjukdomar.” - Clinical electrophysiological methods for investigating visual function in retinal diseases. Course held to ophthalmology fellows in Sweden.
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